Sidekix Dietary Supplement bottles (Overnight Hero and Rise& Thrive products) open with capsules spread on orange background Sidekix Dietary Supplement bottles (Overnight Hero and Rise& Thrive products) open with capsules spread on orange background

The Science Behind Sidekix

There’s no magic here. And we won’t pretend there is.

You may see other supplements promising to fix the side effects of Wegovy, Mounjaro and other GLP-1s with one daily pill and a “proprietary blend.” Be skeptical. That’s not how this works, and a “proprietary blend” usually means they won’t tell you how much of anything you’re actually getting.

We do it differently, and we’ll be honest with you: there’s no secret ingredient in Sidekix. Everything in these bottles is a well-established vitamin, mineral, or botanical, each shown to help with the specific side effects GLP-1 medications bring.

So why not just buy them yourself? You could. You’d come home with eight or ten bottles, spend $130-$180, then have to figure out which to take, how much, and when — and which ones work against each other. It’s complicated, expensive, and easy to get wrong.

We did that work for you. The right ingredients, the right doses, split into a simple morning formula and an evening one. No magic. No mystery blends. No cabinet full of bottles. Two doses a day — that’s it.

Two bottles of Sidekix Dietary Supplements on kitchen counter. Rise & Thrive lists morning support†, anti-nausea†, kidney function†, liver support†, gut+digestion†, muscle support†, 30 capsules. Overnight Hero lists sleep support†, anti-nausea†, constipation aid† and lower bowel+gut support†, 90 capsules. Two bottles of Sidekix Dietary Supplements on kitchen counter. Rise & Thrive lists morning support†, anti-nausea†, kidney function†, liver support†, gut+digestion†, muscle support†, 30 capsules. Overnight Hero lists sleep support†, anti-nausea†, constipation aid† and lower bowel+gut support†, 90 capsules.

Why one pill can’t do the job.

Mornings and nights call for opposite things. The ingredients that ease you into sleep — like magnesium and apigenin — are calming. The ones that fight morning fatigue — like the B vitamins — are energizing. Put them in a single daily pill and they work against each other: you’d be sedated when you need to get going, or stimulated when you’re trying to wind down.

So we built two: Rise & Thrive to support your morning, and Overnight Hero to support your evening, each dosed for what your body actually needs at that time of day.

RISE & THRIVE
Morning (1 capsule)

Bottle of Sidekix Dietary Supplement, Rise & Thrive product. Bottle lists morning support†, anti-nausea†, kidney function†, liver support†, gut+digestion†, muscle support†, 30 capsules. Bottle of Sidekix Dietary Supplement, Rise & Thrive product. Bottle lists morning support†, anti-nausea†, kidney function†, liver support†, gut+digestion†, muscle support†, 30 capsules.

Vitamin B6 (25mg, as Pyridoxal 5-Phosphate)

Has been shown to help reduce nausea. [1] [2]

Vitamin D3 (50mcg, as Cholecalciferol)

Supports muscle function and immune health. [1]

Vitamin B12 (600mcg, as Methylcobalamin)

Supports energy to combat fatigue, and may help reduce nausea associated with GLP-1 medications. [1] [2] [3]

Iron (5mg, as Ferrous Bisglycinate)

Supports energy and healthy red blood cells. We use ferrous bisglycinate — a gentle, well-absorbed form chosen specifically because it’s less likely to cause the constipation that ordinary iron is known for. [1]

Rhodiola Rosea Extract (75mg)

An adaptogen shown to help the body handle stress and reduce fatigue. We use an extract standardized to 3% rosavins and 1% salidroside — the specification used in clinical research. [1]

Ginger Root Extract (75mg, std. 5% gingerols)

A long-established botanical for settling the stomach and easing nausea. Standardized to 5% gingerols — the active compounds behind ginger’s effect. [1]

Astragalus Root Powder (500mg)

Traditionally used to support kidney health. [1]

Bacillus coagulans / LactoSpore® (10mg)

A probiotic that supports digestion and gut comfort. [1]

OVERNIGHT HERO

Evening (3 capsules)

Bottle of Sidekix Dietary Supplement, Overnight Hero product. Bottle lists sleep support†, anti-nausea†, constipation aid† and lower bowel+gut support†, 90 capsules. Bottle of Sidekix Dietary Supplement, Overnight Hero product. Bottle lists sleep support†, anti-nausea†, constipation aid† and lower bowel+gut support†, 90 capsules.

Magnesium (250mg, as Magnesium Glycinate)

Helps ease constipation and supports restful sleep. [1] [2] [3] [4] [5]

Vitamin B6 (10mg, as Pyridoxal 5-Phosphate)

Has been shown to help reduce nausea. [1] [2]

Apigenin (50mg)

A plant compound (found in chamomile) that supports calm and restful sleep. [1]

Bacillus coagulans / LactoSpore® (10mg)

A probiotic that supports digestion and gut comfort. [1]

headshot of person smiling, shoulder-length light brown hair, with tortoiseshell circular earrings and a white medical coat headshot of person smiling, shoulder-length light brown hair, with tortoiseshell circular earrings and a white medical coat

Doctor-reviewed, backed by research.

Sidekix’s formulas were reviewed and approved by our medical advisor, Dr. Wendy Ketner, MD, before production.

“Morning and evening side effects are different problems and need different support. Sidekix uses well-established ingredients at appropriate dosages targeted to the side effects I see most. I reviewed both formulas before production and was glad to approve them.”

— Dr. Wendy Ketner, MD, Medical Advisor

Two bottles of Sidekix Dietary Supplements (Rise & Thrive and Overnight Hero) sitting on white rectangular prisms with bright orange background. Two bottles of Sidekix Dietary Supplements (Rise & Thrive and Overnight Hero) sitting on white rectangular prisms with bright orange background.

Verified by an independent lab.

Every batch of Sidekix is tested by an independent, third-party lab to confirm quality and potency, so what’s on the label is what’s in the bottle.

Real Support, Not a Magic Bullet.

Sidekix is designed to help with the mild to moderate side effects of GLP-1s. Many of its ingredients — like magnesium for digestion and sleep, and B6 and ginger for nausea — can help quickly. But it works best alongside the basics: stay hydrated, get enough fiber, and keep moving. We’ll always tell you the truth about what our products can do. And as always, talk to your doctor about your medication and your health.

Start your Around-the-Clock Sidekick →